Abcam, ab314043, Anti-TOX antibody [BLR212K] - BSA free

Size: 100µL
Rabbit Recombinant Monoclonal TOX antibody. Suitable for Flow Cyt (Intra), IHC-P, IP, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human TOX aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:BLR212K,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:IP, Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TOX aa 50-100. The exact immunogen used to generate this antibody is proprietary information.O94900

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.8 - 8.6Preservative: 0.09% Sodium azideConstituents: 98% Borate buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 12 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TOX gene encodes the TOX protein also known as Thymocyte selection-associated high mobility group (HMG) box protein with a molecular weight of approximately 57 kDa. TOX contains a DNA-binding HMG box domain and operates mechanically as a transcription factor. It expresses mainly in the thymus where it plays a significant role in T cell development. TOX also exhibits expression in lymphoid tissues including the spleen and lymph nodes.
Biological function summary
TOX affects T cell maturation and development particularly during thymocyte selection. The protein contributes critically to the decision-making process that determines whether thymocytes become CD4+ or CD8+ T cells. TOX does not assemble into a known complex but interacts with other developmental transcription factors to influence gene expression patterns in immature T cells. Its expression is tightly regulated to ensure proper immune system development.
Pathways
TOX influences key signal transduction pathways that guide T cell lineage development. It integrates into the T cell receptor (TCR) signaling pathway impacting the expression of genes essential for T cell differentiation. TOX interacts with signaling proteins like Notch1 which affects developmental fate decisions in thymocytes. The balance of these pathways maintains immunity homeostasis and correct immune responses.
TOX links to conditions involving immune dysregulation such as autoimmune diseases and certain lymphomas. Aberrant expression or dysfunction of TOX may contribute to improper immune cell development leading to pathologies like T cell leukemia. In autoimmune diseases altered TOX levels may impact self-tolerance involving proteins such as FOXP3 which governs regulatory T cell function. Understanding TOX's role in these diseases broadens insights into potential therapeutic targets for immune-related diseases.