Abcam, ab314130, Anti-B4GALNT1 antibody [EPR28064-64]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal B4GALNT1 antibody. Suitable for WB, IHC-P, Dot and reacts with Human, Mouse, Rat, Recombinant fragment - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28064-64,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for mouse IHC-P, rat IHC-P

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
B4GALNT1 also known as beta-14-N-acetylgalactosaminyltransferase 1 is an enzyme that plays a role in the biosynthesis of gangliosides. It has a molecular mass of approximately 56 kDa. B4GALNT1 catalyzes the transfer of N-acetylgalactosamine to substrates in the Golgi apparatus which facilitates the formation of gangliosides. This enzyme exhibits expression mainly in the central nervous system and several other tissues reflecting its role in the development and function of neural cells.
Biological function summary
The enzyme contributes to the synthesis of complex gangliosides. B4GALNT1 does not work alone; instead it integrates into a system of glycosylation pathways involving other glycosyltransferases forming a complex network that tailors the composition of glycan structures on lipids and proteins. This activity influences cell recognition adhesion and signaling processes important for neurodevelopment and synapse formation.
Pathways
B4GALNT1 influences the ganglioside biosynthetic pathway an important aspect for proper neuronal function. This pathway involves collaboration with other proteins such as GM2 synthase which cooperates in the addition of sugar residues at various stages of glycolipid formation. These interactions ensure the synthesis of diverse ganglioside molecules within nerve cell membranes which are vital in modulating cellular interactions and signal transduction.
Alterations in B4GALNT1 function have connections to neurological disorders such as Alzheimer's disease and certain types of gangliosidosis. Perturbations in its enzymatic activity can disrupt normal ganglioside composition affecting membrane dynamics and cell signaling. Phenomena linked to other glycosylation enzymes like GM3 synthase also illustrate disease pathways impacted by aberrant glycan synthesis highlighting B4GALNT1's indirect influence on these disorders.