Abcam, ab314235, Anti-HSV1 gH antibody [BBH1] - BSA and Azide free

Size: 100µg / 1mg
Mouse Recombinant Monoclonal GH antibody. Carrier free. Suitable for WB, IHC-P, ICC/IF, IP and reacts with Transfected cell lysate - Herpes simplex virus, Transfected cell line - Herpes simplex virus samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BBH1,
Isotype:IgG2a,
Carrier free:Yes,
Reacts with:Herpes simplex virus,
Applications:WB, ICC/IF, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Cross-reactivity has not been checked and this antibody might cross with HSV-2 gH.

Product details:
ab314235 is the carrier-free version of
ab110227
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSV1 gH also known as glycoprotein H is a significant component of the Herpes Simplex Virus type 1 (HSV-1). The glycoprotein has a molecular mass of approximately 93 kDa and is expressed on the viral envelope. It plays a vital role in the virus's ability to infect host cells. Glycoprotein H functions by facilitating the fusion of the viral envelope with the host cell membrane a critical step for viral entry. Besides its primary expression in HSV-1 this protein shares similarities with entry proteins in other herpesviruses indicating its conserved role across different species.
Biological function summary
Glycoprotein H functions as part of the glycoprotein H-L complex which includes glycoproteins H L and D. This complex orchestrates the fusion process necessary for the virus to penetrate and infect host cells. The glycoprotein H is vital for the stabilization of the complex and contributes to the proper implementation of viral infection processes. Distribution of this protein in the host organism occurs predominantly in epithelial cells which often serve as the initial site of infection. This distribution aids in the rapid spread of the virus within the host.
Pathways
Glycoprotein H is important for the viral entry pathway. The entry involves interactions with host cell surface receptors that mediate viral attachment and fusion. This process places glycoprotein H within the larger context of viral lifecycle pathways interlinked with proteins such as glycoprotein B and glycoprotein D which assist in initial viral attachment and binding to host cells. The coordination among these proteins ensures efficient viral penetration and subsequent replication within the host.
HSV1 gH has a direct connection to herpes simplex infections particularly oral and genital herpes. Its role in viral entry makes it a target for therapeutic interventions aimed at preventing herpesvirus infections. Antibodies targeting glycoprotein H and related viral components can serve as potential treatments by inhibiting virus attachment and entry. Given its role in immune recognition interactions between glycoprotein H and immune cells provide insights into the development of strategies against viral persistence and reactivation particularly in individuals with compromised immune systems.