Abcam, ab314321, Anti-TPSB2 antibody [EPR28111-57]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TPSB2 antibody. Suitable for WB, ICC/IF and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28111-57,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TPSB2 also known as tryptase beta-2 is an enzymatic protein with substantial mechanical significance. It functions as a serine protease typically requiring activation by cleavage. The protein has an approximate mass of 30 kDa. TPSB2 is found mainly in mast cells and to a lesser extent in basophils suggesting its role in immune response. Expression of TPSB2 is not uniform across tissues reflecting its specialized functions.
Biological function summary
Tryptase beta-2 is involved in mediating allergic reactions and inflammation. It is part of a tetrameric complex that consists of identical subunits to perform its catalytic function efficiently. The activity of TPSB2 affects the degradation of extracellular matrix components during inflammatory responses. By modifying structural proteins TPSB2 can facilitate the passage of immune cells to sites of inflammation reinforcing its role in immune surveillance and defense.
Pathways
TPSB2 plays an important role within the immune response and inflammatory pathways. It is intricately connected to mast cell degranulation a process critical in initiating defense mechanisms. TPSB2 interacts with other proteins such as tryptase alpha/beta 1 (TPSAB1) to modulate cellular responses. Furthermore its presence in the kallikrein-kinin system emphasizes its role in modulating vascular inflammation and repair mechanisms.
TPSB2 has associations with allergic conditions like asthma and inflammatory diseases such as arthritis. Its activity influences the severity and progression of these conditions by promoting inflammatory processes. In asthma TPSB2 can contribute to airway remodeling through its interactions with other mast cell proteins like chymase augmenting inflammation and tissue changes. Understanding its mechanism in these diseases offers potential targets for therapeutic interventions.