Abcam, ab314323, Anti-ZFYVE27 antibody [EPR28129-93]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal ZFY27 antibody. Suitable for WB, IP and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28129-93,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFYVE27 also known as Protrudin functions as an active component in intracellular transport processes. The protein has an approximate molecular weight of 50 kDa. It is widely expressed in various tissues with significant levels found in the brain where it interacts with other proteins to facilitate its role in cellular dynamics. ZFYVE27 contains a FYVE domain which aids in binding to phosphatidylinositol 3-phosphate at endosomal membranes supporting its function in membrane trafficking.
Biological function summary
ZFYVE27 plays a role in neurite extension and cellular trafficking. It is not part of a larger complex but interacts independently with other proteins to regulate vesicle formation and transport along microtubules. ZFYVE27 helps in the maintenance of the endoplasmic reticulum's structure and function. Additionally it interacts with proteins like kinesin which assist in the movement of cargo along cellular structures important for proper cell function and communication.
Pathways
ZFYVE27 contributes significantly to the processes of membrane trafficking and neuronal connectivity. It is associated with the endosomal sorting pathway influencing the movement and recycling of vesicles within cells. In this pathway ZFYVE27 interacts with other proteins such as Rab11 which is essential for guiding vesicles to their intended cellular destinations. Additionally it has a role in the axon growth pathway where it cooperates with kinesin motor proteins to promote the elongation and maintenance of neuronal projections.
ZFYVE27 has a connection with hereditary spastic paraplegia (HSP). Mutations in the ZFYVE27 gene lead to neural structural abnormalities contributing to the formation of this neurological disorder characterized by progressive limb spasticity and weakness. The protein interacts with spastin another protein associated with HSP with implications for axonal regeneration and stability. ZFYVE27 also holds a potential link with certain neurodegenerative conditions given its important role in maintaining neuronal network integrity.