Abcam, ab314498, Anti-NLRP6 antibody [EPR28233-48]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal NLRP6 antibody. Suitable for WB and reacts with Mouse, Rat, Transfected cell lysate - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28233-48,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NLRP6 also known as NACHT LRR and PYD domain-containing protein 6 plays a role as a sensor in the immune system. This protein has a mass of approximately 109 kDa. It is expressed in multiple tissues with high levels in intestinal cells and immune-related tissues. NLRP6 functions as part of the inflammasome complex which is important for inducing inflammatory responses by activating caspase-1 and promoting the maturation of inflammatory cytokines such as IL-1β and IL-18.
Biological function summary
NLRP6 has significant roles in maintaining mucosal homeostasis and modulating the body's inflammatory responses. It forms part of the NLRP6 inflammasome complex which impacts immune homeostasis especially within the gut environment. Research indicates that NLRP6 influences both the regulation of the microbiota and the repair processes of the mucosal barrier making it essential for gut health and protection against infections.
Pathways
NLRP6 influences both inflammation and metabolic pathways offering insights into its broad function in immunity. It is a part of the inflammasome pathway which triggers the immune system to combat bacterial infections by activating cytokines. The protein interacts with other inflammasome components like ASC and caspase-1. Additionally NLRP6 is involved in the toll-like receptor (TLR) signaling pathway influencing signal transduction related to immune responses.
Defects in NLRP6 have been linked to inflammatory bowel diseases (IBD) and colitis. Studies show that alterations in NLRP6 function may disrupt gut microbiota balance leading to increased susceptibility to these diseases. Additionally altered NLRP6 activity can connect to colorectal cancer especially with proteins like NF-κB suggesting that its pathways play a role in tumorigenesis by affecting inflammation and immune responses.