Abcam, ab314642, Anti-NRDP1 antibody [EPR26281-19]

Size: 20µL / 100µL / 1mL
Knockout Tested Rabbit Recombinant Monoclonal NRDP1 antibody. Suitable for WB, IP and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26281-19,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NRDP1 also known as Neuregulin Receptor Degradation Protein 1 or FLJ11239 acts as an E3 ubiquitin ligase. It is a critical component for targeting certain proteins for ubiquitination and degradation processes. The protein has a molecular weight of approximately 36 kDa. Researchers have observed its expression in various tissues such as the brain heart and liver indicating its diverse role across different organ systems.
Biological function summary
NRDP1 functions in regulating protein levels within cells by tagging them for degradation. It particularly associates with ErbB3 a member of the epidermal growth factor receptor (EGFR) family and induces its ubiquitination. This interaction reflects NRDP1’s role in controlling cell proliferation signaling. It is not part of any multiprotein complex but has shown the capacity to influence individual protein interactions.
Pathways
Researchers identify NRDP1 as a participant in the ubiquitin-proteasome pathway and the ErbB signaling pathway. In the ubiquitin-proteasome pathway it facilitates the degradation of proteins to maintain cellular proteostasis. NRDP1 interacts with Parkin an E3 ubiquitin ligase associated with mitochondrial quality control. In the ErbB signaling pathway it modulates the function of ErbB receptors impacting cellular responses such as growth and differentiation.
NRDP1 is implicated in cancer and neurodegenerative diseases. Its dysregulation may lead to improper ErbB3 signaling contributing to the development of certain cancers. Abnormal NRDP1 function correlates with neurodegenerative diseases like Parkinson's disease where it interacts with Parkin. These interactions suggest that NRDP1’s role in proteostasis and cell signaling can influence disease progression.