Abcam, ab314897, Anti-CaMKII beta antibody [EPR28076-54]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal KCC2B antibody. Suitable for mIHC, WB, IHC-P, Dot, Flow Cyt (Intra) and reacts with Mouse, Human, Rat, Recombinant fragment - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28076-54,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, WB, Dot, mIHC, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CaMKII beta also called CaM-K 2B is a calcium/calmodulin-dependent protein kinase involved in many cellular processes. It is known for its molecular weight of approximately 73 kDa. Expressed widely in tissues CaMKII beta is particularly important in brain and heart tissues. CaMKII family which includes CaMK plays a role in catalyzing the phosphorylation of serine and threonine residues in proteins influencing varied cellular activities.
Biological function summary
Without referring directly to CaMKII beta this protein contributes to synaptic plasticity which influences learning and memory in neural cells. It functions as part of a multimeric complex forming a holoenzyme with other CaMKII isoforms like CaMKII alpha gamma and delta. The structural dynamics of its autophosphorylation regulate its prolonged activity independent of calcium and calmodulin affecting downstream signaling.
Pathways
Without directly mentioning CaMKII beta it is essential in the Ca2+/calmodulin signaling pathway critical for regulating neuronal activity. Additionally this kinase participates in the cardiac conduction system influencing the heartbeat. Related proteins like calcineurin and protein kinase A interact in these signaling pathways amplifying the role of CaMKII beta in translating calcium bursts into longer-term cellular responses.
Without direct mention CaMKII beta's involvement is evident in conditions such as Alzheimer's disease and arrhythmias. In neurodegenerative diseases its deregulation affects the balance of phosphorylation involving proteins like tau which contribute to disease progression. In cardiac disorders its role in arrhythmias interacts with ion channels affecting heart rhythm stability. Understanding these interactions helps in therapeutic approaches targeting CaMKII beta-related pathways.