Abcam, ab315199, Anti-Ribonuclease A antibody [1B63]

Size: 100µL
Mouse Monoclonal Ribonuclease A antibody. Suitable for WB and reacts with Cow samples. Immunogen corresponding to Synthetic Peptide within Cow RNASE1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1B63,
Isotype:IgG1,
Carrier free:No,
Reacts with:Cow,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Cow RNASE1.P61823

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7 - 8Preservative: 0.03% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ribonuclease A also known as RNase A is a type of ribonuclease enzyme known for its ability to cleave RNA molecules. This enzyme specifically catalyzes the endonucleolytic cleavage of RNA to produce 3'-phosphates and 3'-phosphooligonucleotides terminated by cytidine or uridine. RNase A has a molecular mass of approximately 13.7 kDa and is primarily found in the pancreas of bovines. This protein plays a significant role in RNA metabolism and is often utilized in laboratory research for this purpose.
Biological function summary
Ribonuclease A plays an important role in RNA processing and degradation contributing to the regulation of cellular RNA levels. This enzyme does not operate as part of a larger complex but acts independently to degrade single-stranded RNA. The function of RNase A is essential for maintaining cellular homeostasis by controlling the quantity and quality of the cellular RNA ensuring proper turnover and preventing the accumulation of defective or unnecessary RNA molecules.
Pathways
Ribonuclease A is involved in the RNA degradation pathway which is critical for normal cellular function and gene expression regulation. It collaborates with other nucleases to ensure efficient RNA turnover. RNase A is closely related to proteins like RNase 1 and RNase 5 which also participate in RNA metabolism. Participation of RNase A in this pathway highlights its importance in the regulation of genetic information flow from DNA to RNA.
The malfunction or dysregulation of Ribonuclease A can impact diseases such as cancer and cystic fibrosis. In cancer aberrant RNase A activity can influence RNA levels contributing to unchecked cell proliferation. Moreover RNase A is connected to the inflammation seen in cystic fibrosis via its impact on RNA turnover and immune system signaling. RNase A interactions with proteins such as angiogenin which displays similar enzymatic properties further exemplify its involvement in disease-related pathways.