Abcam, ab315244, Anti-Dynein antibody [EPR28484-147]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Dynein antibody. Suitable for WB and reacts with Human, Mouse, Rat, Recombinant full length protein - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28484-147,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The dynein protein a motor protein also known as cytoplasmic dynein plays an important role in cellular mechanics. It has a molecular mass of approximately 1.2 megadaltons. Dynein functions by converting chemical energy from ATP hydrolysis into mechanical work enabling movement along microtubules toward the minus end. Expressed widely in eukaryotic cells dynein is particularly found in the cytoplasm where it aids intracellular transport processes.
Biological function summary
Dynein facilitates important cellular processes by transporting organelles vesicles and even chromosomes. It is a major component of the dynactin complex a multi-subunit assembly that enhances dynein's affinity for microtubules and cargo. Through its interactions dynein maintains cellular organization and is pivotal in mitosis where it aligns chromosomes and pulls them apart during anaphase.
Pathways
The functionality of dynein interlinks with significant biological pathways such as the intracellular transport pathway and mitotic spindle formation. Partnering with proteins like kinesin dynein ensures the bidirectional transport necessary for cellular homeostasis. Additionally its role in spindle dynamics highlights interaction with spindle assembly checkpoint proteins orchestrating precise chromosome segregation.
Mutations or malfunctions in dynein can lead to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). These disorders arise from defective axonal transport where dynein's role becomes disrupted. In the context of ALS dynein's interaction with superoxide dismutase 1 (SOD1) demonstrates its involvement in neuronal health and pathology. Similarly dynein dysfunction is linked to SMA where alterations affect neuromuscular communication and maintenance.