Abcam, ab315796, Anti-Homeobox protein cut-like 2 antibody [EPR26509-79]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal CUX2 antibody. Suitable for IHC-P and reacts with Mouse, Rat, Transfected cell line - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26509-79,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Homeobox protein cut-like 2 also known as CDP CUX2 or Clox functions as a transcription factor and plays a critical role in regulating gene expression. Mechanically it binds to specific DNA sequences to influence the transcription of target genes. CUX2 has a molecular mass of approximately 150 kDa. Researchers observe its expression in the brain particularly in developing neocortex as well as the adult testis and lymph nodes.
Biological function summary
Homeobox protein cut-like 2 is involved in the development of the nervous system and the regulation of cell growth and differentiation. It is not part of a larger complex but interacts with other transcription factors to modulate these processes. The protein's involvement is significant in neural development impacting neurogenesis and neural patterning. It coordinates with DNA repair pathways as well.
Pathways
Homeobox protein cut-like 2 integrates into neural developmental pathways and cell cycle regulation. In neural development it interacts with other factors like NEUROD1 to influence neuronal differentiation. In cell cycle control it participates in pathways such as the cell proliferation pathway interacting with proteins like p27Kip1 to regulate cell cycle progression and ensure proper cell growth.
Homeobox protein cut-like 2 has an association with neurodevelopmental disorders and cancer. Altered expression or mutations in the protein can lead to developmental abnormalities including neural developmental issues. In cancer abnormal regulation can contribute to tumorigenesis especially in brain-related cancers. It might interact with proteins associated with these conditions such as the tumor suppressor protein p53 indicating its significance in disease mechanisms.