Abcam, ab315877, Anti-MCPIP1 antibody [EPR26062-59]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Anti-MCPIP1 antibody [EPR26062-59] (ab315877) is a rabbit monoclonal antibody detecting MCPIP1 in Western Blot, Dot Blot . Suitable for Human, Mouse . - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26062-59,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-MCPIP1 antibody [EPR26062-59] (ab315877) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Dot Blot in Human, Mouse samples.
What is the molecular weight of MCPIP1?
Anti-MCPIP1 [EPR26062-59] (ab315877) specifically detects a band for MCPIP1 (UniProt: Q5D1E8) at a molecular weight of 65kDa.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR26062-59] also available for your convenience: ab315877, Carrier free -
ab315878
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MCPIP1 (Monocyte Chemotactic Protein-Induced Protein 1) also known by the name Regnase-1 is a protein involved in RNA degradation and inflammation regulation. It acts as an RNase specifically targeting mRNAs for degradation impacting gene expression post-transcriptionally. The protein weighs around 66 kDa and shows expression in various tissues including heart spleen and macrophages. MCPIP1 also demonstrates notable expression in response to external stimuli like lipopolysaccharides.
Biological function summary
MCPIP1 modulates the immune response and inflammation by degrading mRNA of cytokines. Its action helps in controlling inflammation and immune response duration. MCPIP1 interacts with cellular complexes that manage mRNA stability including those involved in decay processes. This activity positions MCPIP1 as a regulator in the production of pro-inflammatory cytokines contributing to the cellular response to external pathogens.
Pathways
MCPIP1 functions within the inflammatory and immune signaling pathways. It is involved in the MAPK pathway which regulates gene expression in response to stress and cytokines. MCPIP1 also interacts with proteins such as TNF-alpha and IL-6 linking it to the inflammatory signaling cascade. These interactions highlight MCPIP1's role in mediating immune and inflammatory pathways contributing to maintaining cellular homeostasis.
MCPIP1 connections relate to inflammatory diseases and autoimmune disorders. Aberrant expression or malfunction of MCPIP1 associates with pathological conditions including rheumatoid arthritis and systemic lupus erythematosus. The regulation of cytokines by MCPIP1 positions it centrally in these conditions as inappropriate levels of proteins like IL-6 and TNF-alpha contribute to disease progression. Consequently MCPIP1 serves as a potential therapeutic target in managing inflammation-driven diseases.