Abcam, ab315904, Anti-ZCWCC1 antibody [EPR28655-56] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal ZCWCC1 antibody. Carrier free. Suitable for IHC-P, Flow Cyt (Intra), ICC/IF, WB, IP and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28655-56,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:Flow Cyt (Intra), IP, ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for mouse and rat IHC.

Product details:
ab315904 is the carrier-free version of
ab315903
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein ZCWCC1 also known as Zinc Finger CW-type Coiled-Coil Domain 1 is a molecular entity with a molecular mass of approximately 85 kDa. ZCWCC1 exists mainly in the nucleus of the cell where it plays a role in the regulation of gene expression. It exhibits a zinc finger motif which allows it to interact with DNA or RNA. Expression of ZCWCC1 is found across various tissue types but it is more prominent in rapidly dividing cells hinting at its involvement in cell cycle regulation.
Biological function summary
ZCWCC1 is implicated in chromatin modification and remodeling affecting how DNA is packed into chromatin. It forms part of a multiprotein complex that facilitates access to specific genetic regions by modifying histones which are proteins around which DNA winds. ZCWCC1 interacting with other proteins in the complex influences transcription and potentially gene silencing. Its function is integral in maintaining the structural configuration of chromatin and ensuring proper gene expression patterns during cellular processes.
Pathways
The activity of ZCWCC1 is integral to the chromatin organization pathway and the gene expression pathway. ZCWCC1 works in conjunction with proteins like histone deacetylases (HDACs) and histone methyltransferases which are vital for modifying histones and regulating gene transcription. These pathways ensure that genetic information is accurately transcribed and translated during various cellular processes including differentiation and proliferation.
ZCWCC1 has potential implications in cancer and neurodegenerative diseases. Aberrant expression or mutation of ZCWCC1 can lead to uncontrolled cell proliferation linking it to oncogenic processes in certain cancers. In neurodegenerative disorders dysregulation of chromatin remodeling where ZCWCC1 is involved is observed alongside factors like tau protein suggesting a complex interplay in neurodegeneration. Understanding ZCWCC1's role in these disease contexts may offer insights into novel therapeutic targets or biomarkers.