Abcam, ab316308, Anti-DKKL1 antibody [EPR25721-68]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal DKKL1 antibody. Suitable for mIHC, ICC/IF, Flow Cyt (Intra), IHC-P, WB and reacts with Rat, Mouse, Human, Transfected cell line - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25721-68,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:ICC/IF, mIHC, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for rat WB.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DKKL1 also known as Dickkopf-like protein 1 is a protein with a mass of approximately 32 kDa. The protein is expressed in several tissues including the testes and brain. DKKL1 belongs to the Dickkopf family which is known for involvement in regulating cellular signaling pathways. Mechanically DKKL1 functions as a modulator in extracellular environments where it can interact with other components of the signaling pathways.
Biological function summary
DKKL1 has roles in cellular differentiation and development processes. While it does not form part of a larger protein complex its function is important in processes that dictate how cells grow and mature. In particular DKKL1 influences key developmental stages possibly affecting the balance between cell proliferation and differentiation.
Pathways
DKKL1 plays a role in the Wnt signaling pathway a critical pathway for cell-to-cell communication during embryonic development and cancer progression. DKKL1's role in modulating this pathway involves interaction with other proteins such as components of the Frizzled receptor family which help transmit signaling from the cell surface to the nucleus dictating cellular responses.
DKKL1 has connections with disorders related to abnormal development and cancer. For example aberrant expression of DKKL1 has been implicated in testicular germ cell tumors where it interacts with proteins such as beta-catenin an important mediator in the Wnt signaling pathway. Alterations in DKKL1 expression can contribute to disrupted signaling potentially leading to tumorigenesis.