Abcam, ab316368, Anti-PPP2R5D antibody [H5D12]

Size: 100µL
Mouse Monoclonal PPP2R5D antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:H5-D12,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform.Q14738

Properties and Storage Information:
Form-Liquid, Storage buffer-Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1 month, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PPP2R5D also known as B56δ forms part of the regulatory subunit of protein phosphatase 2A (PP2A). Protein phosphatase 2A is an important enzyme in cellular signaling that dephosphorylates target proteins. The approximate molecular mass of PPP2R5D is 72 kDa. It is found expressed in various tissues throughout the human body but its levels can vary between different cell types.
Biological function summary
PPP2R5D plays an essential role in the regulation of cell growth and division. This protein is part of the PP2A holoenzyme complex which assembles with catalytic and scaffolding subunits. Through its regulatory influence PPP2R5D affects the phosphorylation state of several substrates thereby impacting cellular processes like cell cycle progression and apoptosis.
Pathways
PPP2R5D significantly contributes to the MAPK signaling pathway and the Wnt pathway. It modulates phosphorylation states affecting signal transduction mechanisms. In the MAPK pathway PPP2R5D interacts with proteins like ERK1/2 by influencing their activity. Similarly in the Wnt pathway it acts on components important for maintaining cellular balance and signaling fidelity.
PPP2R5D mutations and dysregulation have been linked to intellectual disabilities and cancer. Changes in its function are associated with Autism Spectrum Disorder where it potentially interacts with other proteins involved in neuronal development. In cancer altered PPP2R5D activity may disrupt normal cellular growth control often involving proteins like c-Myc that are critical for proliferation and survival.