Abcam, ab31672, Anti-Infectious Bursal Disease (Standard) (IBD) antibody

Size: 200µL
Chicken Polyclonal Infectious Bursal Disease (Standard) (IBD) antibody. Suitable for ELISA and reacts with Infectious bursal disease virus samples. Cited in 1 publication.
Key facts
Host species:Chicken,
Clonality:Polyclonal,
Isotype:IgY,
Carrier free:No,
Reacts with:Infectious bursal disease virus,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:Monospecific for Infectious Bursal Disease.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Purification notes->= 98% No contaminants detected. Single band by SDS-PAGE, IEP and/or RID. Sterile filtered serum produced in SPF (Specific Pathogen Free) chicken embryos., Storage buffer-Constituents: Whole serum, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Infectious Bursal Disease Virus (IBDV) commonly referred to as Gumboro disease affects young chickens mainly targeting the bursa of Fabricius. This virus measures approximately 60 nm in diameter and belongs to the Birnaviridae family. IBDV has a double-stranded RNA genome segmented into two parts. It's widely expressed in young chickens in poultry farms causing considerable concern due to its impact on the poultry industry. The virus is highly infectious resulting in immunosuppression making affected birds susceptible to other infections.
Biological function summary
IBDV targets specific immune cells within the bursa of Fabricius particularly B lymphocytes. By attacking these cells the virus compromises the bird's immune system which plays a central role in the development and differentiation of B cells in chickens. IBDV operates independently rather than as part of a protein complex. The pathogenesis of this virus involves lysis of infected precursor B lymphocytes resulting in a substantial decrease in antibody production.
Pathways
IBDV infection disrupts the normal immune response pathways within the affected bird. The primary pathway involved is the host's adaptive immune response where the virus impairs the humoral immune function. Proteins like VP2 and VP3 of IBDV play significant roles in these pathways affecting the assembly and entry of the virus. Consequently the bird's immune-mediated signaling cascades get disturbed.
IBDV predominantly leads to immunosuppressive disorders in infected poultry. The virus weakens the immune system resulting in secondary infections like Escherichia coli. IBDV can also bring in economic losses due to decreased growth and increased mortality rates in chickens. The viral protein VP3 is significantly connected to these disease states as it influences the virus’s replication and persistence within the host.