Abcam, ab317020, Anti-Integrin beta 8 antibody [EPR27246-85]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Integrin beta 8 antibody. Suitable for Flow Cyt (Intra), WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27246-85,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Not suitable for mouse ICC.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin beta 8 also known as β8 integrin or ITGB8 is a transmembrane protein that functions mechanically as part of the integrin family. It forms heterodimers with the alpha v subunit resulting in the integrin alpha v beta 8 complex. This complex plays a role in cell adhesion and signaling by binding to extracellular matrix proteins like latency-associated peptide TGF-β. Integrin beta 8 is expressed in various tissues notably in the brain lungs and intestinal epithelium. The protein has a mass of approximately 85 kDa.
Biological function summary
Integrin beta 8 participates in the regulation of cellular processes such as growth differentiation and migration. The integrin alpha v beta 8 complex serves as a receptor for latent TGF-β activation an important step in modulating TGF-β signaling. This activation influences processes such as extracellular matrix remodeling and immune response regulation. Integrin beta 8 interacts with actin cytoskeleton regulatory proteins to mediate these cellular changes.
Pathways
Integrin beta 8 influences both TGF-β and Wnt signaling pathways. Its role in TGF-β pathway involves activation of latent TGF-β impacting tissue homeostasis and immune regulation. In connection to Wnt signaling integrin beta 8 modulates cell proliferation and differentiation. The protein shares functional relations with other integrins like integrin beta 6 which also interacts with similar ligands and pathways coordinating cellular response during development and repair processes.
Integrin beta 8 associates with conditions like brain tumors and fibrosis. For example its upregulation in glioblastoma multiforme contributes to the invasive properties of tumor cells by modulating TGF-β signaling similar to the role observed with integrin beta 6 in fibrotic diseases. This connection emphasizes the therapeutic potential of targeting integrin beta 8 to mitigate disease progression and improve treatment efficacy.