Abcam, ab317097, Anti-STAM antibody [HL1635]

Size: 100µL
Rabbit Monoclonal STAM1 antibody. Suitable for WB, ICC/IF and reacts with Transfected cell lysate, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human STAM.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1635,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human STAM.Q92783

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STAM or Signal Transducing Adaptor Molecule is a protein involved in intracellular signaling pathways. It is also known by the alternate name STAM-1 and has a mass of approximately 55 kDa. STAM is expressed in various tissues with a significant presence in the immune and hematopoietic systems. Its mechanical role involves interacting with different cellular components to facilitate signal transduction. The protein mainly localizes to the cytoplasm and occasionally associates with membrane-bound organelles.
Biological function summary
STAM engages in processes that are essential for signal transduction and endosomal sorting. It works as part of a larger protein complex known as the ESCRT-0 complex which is important for regulating endocytosis and sorting of ubiquitinated membrane proteins. This complex includes other proteins such as Hrs and plays a role in the degradation of signaling receptors assisting in modulating cell signaling and maintaining cellular equilibrium.
Pathways
STAM is implicated in the endocytic and ubiquitin-proteasome systems. It interacts significantly with the endocytosis pathway participating in the sorting of endocytic vesicles. In this context STAM's function involves cooperation with proteins like Hrs in the ESCRT machinery which manages membrane receptor recycling and degradation. By controlling these pathways it modulates signal transduction and influences cell fate decisions.
STAM's dysfunction is linked to certain conditions including cancer and neurodegenerative diseases. In cancer aberrant STAM function can result in uncontrolled cellular proliferation as seen with its association with proteins such as c-MET a receptor tyrosine kinase. In neurodegenerative diseases malfunction of STAM can disrupt cellular homeostasis and protein degradation pathways contributing to neuronal cell death. Understanding STAM's interactions and pathways can provide insights into potential therapeutic targets for these diseases.