Abcam, ab317119, Anti-SUN1 antibody [HL1947]

Size: 100µL
Rabbit Monoclonal SUN1 antibody. Suitable for IHC-P, ICC/IF, WB and reacts with Human, Mouse, Transfected cell lysate samples. Immunogen corresponding to Recombinant Fragment Protein within Human SUN1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1947,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SUN1.O94901

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SUN1 also known as Sad1-Unc-84 homology 1 is a protein with a molecular mass of approximately 97 kDa. This protein is an important component of the nuclear envelope which helps maintain the structure of the nucleus. It is expressed in various tissues including muscle and neurons and is an integral part of the linking complex that connects the nuclear envelope to the cytoskeleton. SUN1 functions as a structural protein and contributes to the mechanical stability of the nuclear architecture.
Biological function summary
SUN1 plays significant roles in cellular functions through its interaction with other proteins. It is an essential part of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex where it interacts with KASH domain-containing proteins that span the outer nuclear membrane. This interaction is important for nuclear positioning centrosome attachment and chromosomal movement. SUN1 participates in critical processes such as DNA repair and meiotic progression influencing cell cycle regulation and genetic stability.
Pathways
SUN1 integrates into cellular communication systems by mediating mechanical signals across the nuclear-cytoplasmic boundary. It is actively involved in the nuclear envelope-endoplasmic reticulum network which is critical for nuclear-cytoskeletal coupling. The protein associates with SUN2 another member of the SUN family and they both interact with the Nesprin proteins anchoring the nucleus to the cell's structural framework. This association enables SUN1 to influence signaling pathways related to cell division and differentiation.
Mutations and malfunctions within the SUN1 protein have been associated with several medical conditions. Its role is particularly noted in certain muscular dystrophies and nuclear envelopathies where mutations disrupt nuclear-cytoskeletal connections. In these pathological states SUN1 has links with proteins like Emerin which also reside at the nuclear envelope and whose dysfunction causes Emery-Dreifuss muscular dystrophy. These interconnections highlight the importance of SUN1 in maintaining cellular integrity and function particularly in muscle and nerve cells.