Abcam, ab317177, Anti-IPMK antibody [HL2244]

Size: 100µL
Rabbit Monoclonal IPMK antibody. Suitable for WB and reacts with Transfected cell lysate, Human, Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human IPMK.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2244,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IPMK.Q8NFU5

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The inositol polyphosphate multikinase (IPMK) also known as Ipk2 or Arg82 functions as an important enzyme that catalyzes the phosphorylation of inositol phosphates. IPMK performs its functions by converting inositol 145-trisphosphate to inositol 1345-tetrakisphosphate. The protein weighs approximately 45 kDa and is expressed in various tissues including the brain liver and kidney. In these tissues IPMK interacts with cellular components to regulate its activity further.
Biological function summary
The enzyme IPMK plays a significant role in cellular signaling processes and acts as a part of the inositol phosphate metabolic pathway. It participates in the regulation of gene expression by associating with transcription factors and chromatin remodeling complexes. Researchers have identified it as contributing to both nuclear and cytoplasmic signaling and its impact on processes like cell proliferation and apoptosis is well documented.
Pathways
IPMK engages in critical intracellular signaling networks such as the PI3K/AKT pathway which influence cell growth and survival. It links with other proteins like PI3K enhancing the pathway's browser of growth factors. In the inositol signaling pathway IPMK interacts with kinases and phosphatases illustrating its function in modulating cellular responses to external stimuli. These pathways help with the organism's development and maintenance by guiding important cellular functions.
IPMK has been associated with conditions like cancer and neurodegenerative disorders. In cancer its regulation of the PI3K/AKT pathway associates it with oncogenic processes where abnormal cell growth occurs. In neurodegenerative disorders studies suggest IPMK interaction with proteins involved in neuroprotection like AKT may influence disease progression. This relationship opens avenues for therapeutic strategies targeting IPMK and its related pathways to mitigate the adverse effects of these diseases.