Abcam, ab317179, Anti-RPLP2 antibody [HL2256]

Size: 100µL
Rabbit Monoclonal RPLP2 antibody. Suitable for IHC-P, ICC/IF, WB and reacts with Human, Mouse, Rat, Zebrafish samples. Immunogen corresponding to Recombinant Fragment Protein within Human RPLP2.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2256,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat, Zebrafish,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RPLP2.P05387

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPLP2 also known as the Ribosomal Protein Lateral Stalk Subunit P2 is a component of the ribosomal assembly. It has a molecular weight of approximately 11 kDa. This protein performs an integral role in the formation and function of the 60S ribosomal subunit facilitating protein synthesis in the cell. RPLP2 is expressed in various tissues indicating its widespread importance in cellular activities and functions.
Biological function summary
RPLP2 contributes to essential cellular processes by being part of the ribosomal complex. This protein works in concert with other ribosomal P proteins to form the lateral stalk of the ribosome important for translational function. Within the ribosome RPLP2 helps in the binding of elongation factors impacting protein elongation during translation. The interaction of these proteins as part of the ribosome highlights their significance in cell growth and proliferation.
Pathways
RPLP2 plays a significant role in translation and protein synthesis pathways. It is involved in the translation initiation pathway which is important for starting mRNA translation into proteins. In this context RPLP2 interacts with other ribosomal components such as RPLP0 and RPLP1 contributing to the dynamic process of translation. These interactions are critical for the pathway's function ensuring accurate and efficient protein synthesis.
RPLP2 has associations with certain conditions like cancer and ribosomopathies. Abnormal expression or malfunction of RPLP2 may disrupt protein synthesis potentially leading to oncogenesis or growth disorders. Changes in RPLP2 can impact pathways involving related proteins such as other ribosomal proteins which when altered influence disease development. Understanding these connections helps in researching therapeutic interventions targeting protein synthesis dysregulation.