Abcam, ab317186, Anti-GPS2 antibody [HL2276]

Size: 100µL
Rabbit Monoclonal GPS2 antibody. Suitable for IHC-P, WB and reacts with Mouse, Rat, Human, Zebrafish samples. Immunogen corresponding to Recombinant Fragment Protein within Human G protein pathway suppressor 2.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL2276,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat, Zebrafish,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human G protein pathway suppressor 2.Q13227

Properties and Storage Information:
Form-Liquid, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPS2 also known as G protein pathway suppressor 2 carries out significant functions at the molecular level. This protein has a mass of approximately 37 kDa and is expressed in various tissues including the liver heart and muscles. GPS2 acts in cellular environments by interacting with other proteins to regulate signaling and gene expression. It impacts cellular communication by linking receptors to downstream effectors. Several forms of this protein exist which are involved in different cellular processes demonstrating its versatility.
Biological function summary
GPS2 serves key roles in regulating transcriptional activity. It forms part of the corepressor complex which is essential in modifying chromatin structure to control gene expression. By restricting activation of certain genes GPS2 helps maintain cellular homeostasis and prevent excessive cellular responses. Through its actions GPS2 ensures that cells respond appropriately to external stimuli and can adapt to changing conditions.
Pathways
GPS2 integrates into the MAPK and NF-kB signaling pathways. It interacts with other proteins like HDAC3 and NCoR which assist in regulating gene transcription linked to these pathways. This relationship helps modulate responses to stress and inflammatory signals providing balance in cell growth and death processes. GPS2's participation in these pathways indicates its importance in signal transduction and cellular defense mechanisms.
GPS2 plays a part in metabolic syndrome and certain cancers. Disruptions in GPS2 function can lead to improper lipid metabolism and insulin resistance contributing to the metabolic syndrome. In the context of cancer GPS2's interactions with proteins like NCoR can influence tumor progression by altering the expression of genes involved in cell proliferation. Understanding GPS2's connection in these conditions provides insights into potential therapeutic targets for related diseases.