Abcam, ab317303, Anti-Neuroligin 2 antibody [EPR28230-122]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Neuroligin 2 antibody. Suitable for IHC-P, IP, IHC-Fr, ICC/IF, Flow Cyt and reacts with Transfected cell line - Mouse, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28230-122,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:ICC/IF, Flow Cyt, IHC-P, IP, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for rat ICC

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuroligin 2 also known as NLGN2 is a postsynaptic cell adhesion molecule with a mass of approximately 106 kDa. It plays an important role in forming and maintaining synaptic connections which are essential for communication between neurons. Neuroligin 2 is predominately expressed in the central nervous system and can be found at inhibitory synapses where it interacts with other synaptic proteins to maintain synaptic structure and function.
Biological function summary
This synaptic adhesion protein plays a part in the formation of synapses and the modulation of synaptic strength. Neuroligin 2 forms a trans-synaptic complex with neurexins on the presynaptic side which helps to stabilize synapses by mediating cell-cell interactions. This interaction is important for maintaining balance between excitatory and inhibitory signals in the brain which contributes to normal brain function and neuronal communication.
Pathways
Neuroligin 2 functions as an integral part of synaptic signaling and neural network activity. It is connected to synaptic pathways that govern synapse assembly which involves other proteins like PSD-95. In particular its interaction with neurexins plays a role in the formation of the inhibitory synapses pathway which regulates inhibitory neurotransmission. Through these pathways Neuroligin 2 influences how neurons communicate and process information within neural circuits.
This protein associates with certain neurological and psychiatric conditions. Altered Neuroligin 2 function has links to autism spectrum disorders and schizophrenia. In these diseases its interaction with proteins such as neurexin may be disrupted which can impact synaptic balance and lead to deficits in synaptic function. Studying Neuroligin 2 helps to understand these disorders better and potentially develop therapeutic strategies targeting synaptic adhesion molecules.