Abcam, ab317384, Anti-DHRS1 antibody [S01-9E4]

Size: 100µL
Rabbit Monoclonal Dhrs1 antibody. Suitable for WB and reacts with Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human DHRS1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:S01-9E4,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DHRS1.Q96LJ7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHRS1 also known as dehydrogenase/reductase SDR family member 1 is an enzyme involved in biochemical reactions. It belongs to the short-chain dehydrogenase/reductase (SDR) family and has a mass of about 33 kDa. This enzyme participates in redox reactions specifically by catalyzing the oxidation and reduction processes involving small substrates. DHRS1 is mainly expressed in liver and kidney tissues which suggests its role in metabolic processes associated with these organs.
Biological function summary
DHRS1 plays an important role in lipid metabolism. It helps in the conversion of steroid precursors and participates in the inactivation of steroid hormones. This enzyme does not form part of a complex but interacts with other enzymes within the same family to maintain balanced metabolic functions. Its activity assists in ensuring proper physiological levels of various metabolites and hormones.
Pathways
DHRS1 integrates into the lipid metabolism and steroid hormone biosynthesis pathways. It interacts with key proteins involved in oxidative metabolism such as 11β-hydroxysteroid dehydrogenase contributing to the regulation and conversion processes within these pathways. These interactions are important in controlling the balance of metabolites and support the physiological functionality of lipids and hormones.
DHRS1 is associated with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Changes in DHRS1 activity can affect lipid processing and hormone regulation leading to these metabolic conditions. It may connect to proteins like peroxisome proliferator-activated receptor gamma (PPARγ) which also influences lipid metabolism and has a role in the onset of metabolic diseases. Understanding DHRS1's interactions and alterations could provide insight into therapeutic targets for these conditions.