Abcam, ab317386, Anti-GPCR GPR37 antibody [S02-9I6]

Size: 100µL
Rabbit Monoclonal GPCR GPR37 antibody. Suitable for WB and reacts with Rat samples. Immunogen corresponding to Synthetic Peptide within Human Prosaposin receptor GPR37.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:S02-9I6,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Prosaposin receptor GPR37.O15354

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GPCR GPR37 also known as the Parkin-associated endothelin-like receptor (Pael-R) is a G protein-coupled receptor with a significant role in cellular signaling. This receptor weighs approximately 59 kDa and it expresses broadly in the brain specifically in the nigrostriatal dopaminergic neurons and also in other tissues such as heart and liver. GPR37 is embedded in the cell membrane where it interacts with various ligands to initiate intracellular signaling cascades.
Biological function summary
GPR37 influences pathways that regulate neurotransmitter release and uptake playing a role in neurological function. It forms part of a complex that involves other signaling proteins. This interaction impacts the dopaminergic system which is essential for controlling movement and emotional responses. GPR37's activity affects cellular processes that maintain neuronal health and synaptic plasticity therefore contributing to normal neurological functions.
Pathways
GPCR GPR37 engages in the MAPK signaling and endocytosis pathways. It interacts with proteins like GPR37L1 which shares structural similarities and functional overlaps. The engagement within the MAPK signaling pathway influences cellular differentiation proliferation and survival. Through the endocytosis pathway GPR37 participates in the internalization and recycling of membrane receptors modulating response to extracellular signals.
GPR37 has an established connection with Parkinson's disease due to its involvement in dopaminergic neuron function. Misfolded GPR37 aggregates are associated with neurotoxicity a hallmark of Parkinson’s pathology. Additionally this receptor links to mood disorders particularly depression where disturbances in dopamine signaling are observed. Its interaction with the protein parkin an E3 ubiquitin ligase is significant in these conditions as dysfunctional parkin or GPR37 may lead to impaired proteasomal degradation and accumulation of toxic proteins.