Abcam, ab317429, Anti-NgR3 antibody [S03-6C3]

Size: 100µL
Rabbit Monoclonal NgR3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human RTN4RL1.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:S03-6C3,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RTN4RL1.Q86UN2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NgR3 also known as Nogo-66 Receptor Homolog 3 or Reticulon 4 Receptor-Like 2 is part of the Nogo receptor family. It is a glycolipid-anchored receptor weighing approximately 55 kDa. This protein is mainly found in the central nervous system and is widely expressed in the brain though it also appears in other tissues to a lesser extent. NgR3 contributes to axon growth inhibition and neuronal regeneration influencing nerve repair processes.
Biological function summary
NgR3 influences axonal guidance and inhibition by interacting with other proteins. It forms part of a receptor complex typically incorporating p75 neurotrophin receptor and Lingo-1 which are important for signaling processes. Through these interactions NgR3 helps moderate the effects of myelin-associated inhibitors on axonal outgrowth supporting the regulation of neuronal plasticity and myelin repair mechanisms.
Pathways
This receptor plays a significant role in the regulation of axon regeneration. It intersects with the Nogo-A signaling pathway where it works with closely related proteins such as NgR1 and NgR2. These interactions inhibit axonal growth and impact neuronal development and recovery post-injury. Through this pathway NgR3 aids in balancing axonal regeneration and pathfinding during neural development and repair.
NgR3 is associated with conditions that involve axonal damage and neurodegeneration including multiple sclerosis and spinal cord injuries. It impacts these conditions by modulating axonal growth inhibitory mechanisms. In multiple sclerosis NgR3 works with proteins like Nogo-A to influence remyelination processes potentially affecting the disease progression. Understanding the role of NgR3 in these contexts could aid in developing therapeutic strategies aimed at enhancing neural repair and recovery.