Abcam, ab317578, Anti-CCXCR1/XCR1 antibody [CIA207A]

Size: 20µg / 100µg / 1mg
Rat Recombinant Monoclonal CCXCR1/XCR1 antibody. Suitable for I-ELISA, IHC-P and reacts with Recombinant fragment - Human, Human samples.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:CIA207A,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCXCR1 also known as XCR1 is a chemokine receptor belonging to the C class of chemokine receptors. It has a molecular mass of approximately 38 kDa. Structurally CCXCR1 is a G protein-coupled receptor (GPCR) with seven transmembrane domains. It is selectively expressed in dendritic cells particularly in lymphoid tissues and a small subset of CD8+ T cells. CCXCR1 interacts specifically with its ligand XCL1 also known as lymphotactin to perform its function.
Biological function summary
CCXCR1 plays a significant role in immune responses by guiding the migration of dendritic cells to regions of inflammation or infection. This receptor is not part of a larger complex but works independently to achieve its function. It is essential in antigen cross-presentation enabling effective activation of cytotoxic T cells. This function is important for maintaining immune surveillance and initiating immune responses against pathogens.
Pathways
CCXCR1 is an important player in the chemokine signaling pathway and immune response regulation. It cooperates with proteins like CCR7 which also direct dendritic cell migration but to different lymphoid compartments. CCXCR1's activity influences the direction of cell migration helping cells find specific locations where their action is needed. Such coordination is vital for appropriate immune cell trafficking and function within immune systems.
CCXCR1 involvement has a significant link with autoimmune diseases like lupus. Its role in dendritic cell trafficking suggests a part in the defective immune responses observed in these disorders. Additionally research indicates its possible connection to certain cancers where its expression may affect tumor immune evasion. CCXCR1 activity and its regulation could influence disease severity or progression making it a potential target for therapeutic strategies.