Abcam, ab317602, Anti-TAB2 antibody [EPR19670-161]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TAB2 antibody. Suitable for WB, IP and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR19670-161,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAB2 also known as TGF-beta-activated kinase 1 binding protein 2 or MAP3K7IP2 is an adapter protein with a mass of approximately 71 kDa. It plays a mechanical role in the nuclear and cytoplasmic compartments acting as a critical component in signaling pathways. Its expression is notable in various tissues including the heart placenta and skeletal muscle. TAB2 mainly functions by interacting with kinases to relay and amplify signals in the cell especially those related to inflammation and stress responses.
Biological function summary
TAB2 maintains a significant position in cellular signaling as part of larger protein complexes. It associates with TAK1 (transforming growth factor-beta-activated kinase 1) to regulate NF-kappaB and MAPK pathways. Through these interactions TAB2 helps cells respond to environmental signals mediating transcriptional responses necessary for adaptation and defense mechanisms. In particular TAB2's role in these complexes underlines its importance in immune response modulation and cellular homeostasis.
Pathways
TAB2 is deeply involved in both the NF-kappaB and MAPK signaling pathways where it cooperates intimately with proteins such as TAK1 and TAB1. These pathways are essential for gene expression regulation in response to pro-inflammatory signals. TAB2 facilitates the activation of IKK complex within the NF-kappaB pathway and JNK in the MAPK pathway. By influencing these pathways TAB2 governs important cellular processes like apoptosis proliferation and differentiation.
TAB2's dysfunction has strong connections with inflammatory and cardiovascular diseases. Its interaction with TAK1 and other proteins can lead to aberrant signaling therefore associating TAB2 with conditions such as rheumatoid arthritis and cardiac hypertrophy. In cardiomyopathies for instance disturbances in TAB2's function can affect signal transduction significantly impacting cardiac muscle structure and function. Understanding TAB2 and its intricate network of protein interactions aids in uncovering therapeutic targets for these diseases.