Abcam, ab317727, Anti-TDRD3 antibody [RAB-C419]

Size: 100µg
Human Recombinant Monoclonal TDRD3 antibody. Suitable for WB, Flow Cyt (Intra), ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human TDRD3 aa 550-650.
Key facts
Host species:Human,
Clonality:Monoclonal,
Clone number:RAB-C419,
Isotype:Unknown,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TDRD3 aa 550-650. The exact immunogen used to generate this antibody is proprietary information.Q9H7E2,
Specificity:This antibody recognizes TDRD3 (Tudor domain-containing protein 3). It binds to a folded domain, amino acids 1-455.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified by Immobilized Metal Affinity Chromatography., Storage buffer-pH: 7.2Preservative: 0.02% Proclin 300Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TDRD3 also known as Tudor domain-containing protein 3 executes important functions within the cell. It has a mass of approximately 75 kDa. TDRD3 is known for its expression in various tissues with higher levels found in brain and liver. Its structural makeup includes a Tudor domain which helps it recognize and bind methylated arginine residues on proteins. The presence of such a domain is vital for its role in mRNA regulation and protein interaction.
Biological function summary
TDRD3 influences several processes related to mRNA dynamics and gene expression. It forms a part of the transcriptional co-activator complex that interacts with the RNA polymerase II machinery. Through this TDRD3 enhances transcription elongation playing a role in gene expression regulation. Additionally it interacts with other proteins like FMRP and PRMT1 establishing a close association with RNA-binding processes and methylation activities.
Pathways
The role of TDRD3 integrates into notable biological mechanisms like the mRNA processing and DNA damage response pathways. In the mRNA processing pathway TDRD3 collaborates with proteins such as CBC (cap-binding complex) which are essential for the maturation of mRNA. In the DNA damage response pathway TDRD3 works alongside factors like TopBP1 contributing to the activation and proper functioning of repair machinery.
Several insights link TDRD3 to cancer and mental disorders like Fragile X syndrome. Its interaction with FMRP known for its connection to Fragile X syndrome indicates a potential role in neural development abnormalities. Moreover altered TDRD3 expression and function in cancer supports its relevance to tumor progression often in coordination with proteins involved in the DNA repair pathway such as TopBP1. Understanding these associations aids in targeting TDRD3 for therapeutic applications.