Abcam, ab318132, Anti-XRN2 antibody [EPR28598-13]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal XRN2 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra), ICC/IF and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28598-13,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, ICC/IF, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb
patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
XRN2 also known as 5'-3' exoribonuclease 2 is an enzyme involved in RNA metabolism. It has a molecular mass of approximately 105 kDa. XRN2 scavenges for the degradation of uncapped nascent RNA by cleaving RNA in the 5' to 3' direction after exonucleolytic cleavage. Predominantly expressed in the nucleus XRN2 plays an important role in RNA turnover and processing contributing to the precise control of gene expression within eukaryotic cells.
Biological function summary
5'-3' exoribonuclease 2 regulates the termination of transcription facilitating the completion of the RNA synthesis process. XRN2 functions in coordination with other components within transcription termination complexes such as the exosome. These complexes ensure the removal of excess or faulty RNA which is critical for maintaining cellular homeostasis. XRN2's activity aids in silencing transcriptional noise and preventing the accumulation of defective RNA species.
Pathways
5'-3' RNA decay and termination are where XRN2 finds its primary function. It is a part of the exosome-mediated RNA decay pathway and contributes to effective gene expression pathways. In these pathways XRN2 functions alongside proteins such as Rrp6 and other cofactors ensuring the fidelity of RNA processing is maintained. It interacts with proteins involved in RNA polymerase II-mediated transcriptional processes highlighting its integral role in gene expression regulation.
Improper function or expression of XRN2 is linked to cancer and neurodegenerative diseases. In cancer alterations in RNA processing pathways involving XRN2 can lead to unchecked cellular proliferation. Additionally proteins like SEPT7 are sometimes altered in these pathways contributing to oncogenic potentials. In neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) disrupted XRN2 function can result in abnormal RNA processing and neuronal damage. Here interactions with proteins like TDP-43 can exacerbate disease pathology linking XRN2 to complex disease mechanisms.