Abcam, ab318185, Anti-SFRP2 antibody [EPR26088-157]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal SFRP2 antibody. Suitable for Dot, WB and reacts with Recombinant full length protein - Human, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26088-157,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Dot, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SFRP2 also known as Secreted Frizzled-Related Protein 2 is a protein that primarily functions as a modulator of the Wnt signaling pathway. It is a secreted glycoprotein with an approximate mass of 35 kDa. SFRP2 contains a cysteine-rich domain that is homologous to the Wnt-binding site of Frizzled proteins. This protein is widely expressed in various tissues including the heart lung and kidneys. Its primary role involves regulating the activity of Wnt proteins by direct binding which impacts cell signaling processes.
Biological function summary
SFRP2 plays a significant role in the regulation of cellular proliferation migration and differentiation. It often functions as a part of extracellular signaling complexes influencing tissue development and repair. SFRP2 has been implicated in controlling the balance between cell growth and apoptosis particularly in stem cell environments and developing organ systems. Its activity impacts embryonic development contributing to the formation and patterning of tissues by modulating the Wnt signaling cascade.
Pathways
Scientists have extensively studied SFRP2 in the context of the Wnt signaling and angiogenesis pathways. In the Wnt signaling pathway SFRP2 intervenes by sequestering Wnt ligands and preventing them from activating Frizzled receptors thereby modulating downstream β-catenin activities. The protein shows interaction with other Wnt pathway components like DKK1 which also modulates Wnt signaling. In the angiogenesis pathway SFRP2's involvement affects vascular formation and stability linking it to proteins such as VEGF a critical regulator of blood vessel growth.
Researchers have linked SFRP2 to cancer and cardiac conditions. In cancer abnormal SFRP2 expression has been associated with tumor progression and metastasis often through its interaction with other Wnt pathway proteins like β-catenin and DKK1 altering cell survival and division. In cardiac disorders altered levels of SFRP2 impact heart remodeling and fibrosis connecting to proteins such as TGF-β involved in fibrotic processes. Scientists continue to investigate SFRP2's role in these conditions to develop targeted therapeutic strategies.