Abcam, ab31828, Anti-p38 delta/MAPK13 + p38 alpha/MAPK14 antibody [M138]

Size: 100µL
Knockout Tested Mouse Monoclonal MK14 antibody. Suitable for WB, ICC/IF, ELISA, IHC-P, Flow Cyt (Intra) and reacts with Human, Recombinant full length protein - Human, Syrian hamster, Vervet monkey, Dog, Cow, Rat, Mouse, African green monkey, Synthetic peptide samples. Cited in 224 publications. Immunogen corresponding to Recombinant Fragment Protein within Rat Mapk14.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:M138,
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse, Human, Cow, Rat, Dog, Syrian hamster, African green monkey,
Applications:ICC/IF, ELISA, IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Rat Mapk14. The exact immunogen used to generate this antibody is proprietary information.P70618,
Epitope:ab31828 recognises an epitope located in the C terminal region of p38.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified with protein A affinity chromatography., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P38 delta (MAPK13) and p38 alpha (MAPK14) are important members of the mitogen-activated protein kinase (MAPK) family. These proteins act as serine/threonine kinases and mediate signal transduction for various cellular processes including stress response cell differentiation and apoptosis. p38 delta typically weighs about 43 kDa. Both kinases are widely expressed in different tissues—such as the heart liver and immune cells—indicating their broad role in normal cellular functions and responses to external stimuli.
Biological function summary
These kinases participate in the cellular stress response and inflammation. They do not form part of a stable protein complex but instead interact dynamically with other proteins including upstream MAPK kinases. Both p38 delta and p38 alpha get activated by environmental stressors like UV radiation and pro-inflammatory cytokines leading to the phosphorylation of target substrates like transcription factors. Through this interaction they regulate gene expression critical for survival and adaptation to stress.
Pathways
P38 delta and alpha integrate into MAPK signaling pathways. Within these pathways they modulate responses to stress and growth signals. Specifically they relate to the JNK and ERK signaling routes albeit having distinct yet overlapping functions. Both kinases coexist relationally with other proteins; for instance they share upstream activators like MKK3 and MKK6 which further connects them to signal amplification and target divergence in cellular responses.
P38 delta and alpha have roles in inflammatory diseases and cancer. For instance overactivity of these kinases contributes to chronic inflammatory conditions like rheumatoid arthritis and is implicated in tumorigenesis affecting cellular proliferation and survival mechanisms. Through these conditions p38 delta and alpha connect with pro-inflammatory cytokines and oncogenes respectively magnifying their pathological footprint in disturbed cellular environments.