Abcam, ab318283, Anti-CXCL10/IP-10 antibody [RM2054] - BSA and Azide free

Size: 100µg / 1mg
Knockout Tested Rabbit Recombinant Multiclonal IP10 antibody. Carrier free. Suitable for IHC-P, WB, ICC/IF, IP, Flow Cyt (Intra) and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RM2054,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WB, IP, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab318283 is the carrier-free version of
ab318282
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CXCL10 also known as Interferon Gamma-Induced Protein 10 (IP-10) is a chemokine with a molecular mass of about 10 kDa. This protein functions by binding to its receptor CXCR3 and plays a central role in the immune response by modulating the migration of immune cells particularly T cells NK cells and macrophages to inflamed tissues. CXCL10 is highly expressed in a variety of cell types including monocytes fibroblasts endothelial cells and various epithelial cells especially following stimulation by interferons or lipopolysaccharides.
Biological function summary
This chemokine mediates the effects of immune responses through its ability to attract and activate leukocytes. It does not form part of larger protein complexes functioning independently to influence inflammation and tissue damage repair processes. Its activity largely influences the immune surveillance system facilitating the body's ability to combat pathogens and abnormal cells by directing immune cells to sites that need a defense.
Pathways
CXCL10 functions in the context of the JAK-STAT signaling pathway which regulates gene expression in response to cytokines. It also plays a role in the NF-kB pathway a critical regulator of immune responses inflammation and cell proliferation. Through these pathways CXCL10 interacts with other chemokines and cytokines such as CXCL9 and CXCL11 affecting the recruitment and activation of CXCR3-expressing cells.
CXCL10 relates closely to autoimmune conditions and chronic inflammation such as rheumatoid arthritis and inflammatory bowel disease. It collaborates with CXCL9 in the inflammatory cascade contributing to the pathology of these diseases by maintaining a cycle of immune cell recruitment and sustained tissue damage. Understanding the role of CXCL10 in these diseases can help develop therapeutic strategies that modulate its expression or block its interaction with its receptor CXCR3 to control excessive inflammation and tissue damage.