Abcam, ab319037, Anti-Netrin G1 antibody [EPR27984-506]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Netrin G1 antibody. Suitable for WB, IHC-P and reacts with Transfected cell lysate - Human, Human, Rat, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27984-506,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Mouse testis showed non-specifc staining, and mouse kidney, colon, stomach showed weak staining.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Netrin G1 also known as Netrin-G1 or NTNG1 is a protein involved in axonal guidance. This protein helps in the development and differentiation of the central nervous system. It has a mass of approximately 64 kDa. Netrin G1 is expressed in brain regions such as the hippocampus and cerebral cortex. Unlike other netrins it is tethered to the membrane through a glycosylphosphatidylinositol (GPI) anchor affecting its signaling properties.
Biological function summary
Netrin G1 plays a significant role in neuronal circuit formation. It interacts with ligands like NGL1 and NGL2 to mediate cell signaling pathways that guide axonal growth and synapse formation. While it is not a part of a molecular complex on its own its association with these partners enhances its functionality in synaptic connectivity and neural network maintenance.
Pathways
Netrin G1 engages in the axon guidance pathway and is involved in nervous system development processes. It works alongside proteins such as Netrin-1 to influence the direction and growth of axons. Through these interactions Netrin G1 contributes to the precise wiring of the nervous system required for proper function. Understanding its role in these pathways provides insight into the molecular mechanisms of neural development.
Changes in Netrin G1 expression and function have been linked to neuropsychiatric conditions like schizophrenia and autism spectrum disorders. Studies suggest that Netrin G1 through its interaction with other proteins like Netrin-1 and DCC can alter synaptic connectivity which may play a role in the pathology of these conditions. These associations make Netrin G1 a potential target for therapeutic interventions in related neurological disorders.