Abcam, ab319051, Anti-ZFYVE26 antibody [EPR28782-59]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal ZFY26 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28782-59,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZFYVE26 also known as spastizin is a protein with a mass of approximately 260 kDa. It functions as a zinc finger FYVE-type containing protein which participates in intracellular trafficking and endosomal transport. ZFYVE26 locates in the cytoplasm and its expression appears in many tissues but it is particularly abundant in the nervous system where it suggests an important cellular role. Through its FYVE domain it directly binds to phosphatidylinositol 3-phosphate (PtdIns3P) on endosomal membranes a feature that defines its mechanical operation.
Biological function summary
ZFYVE26 regulates endosome-to-trans-Golgi network trafficking and may also facilitate autophagic processes. It forms part of a protein complex involved in shaping the tubular endosomal networks working alongside other proteins like spatacsin. This association aids in maintaining cellular homeostasis by preventing the accumulation of dysfunctional endosomes. ZFYVE26 also influences the stability and positioning of the cytoskeleton by interacting with specific cytoskeletal components.
Pathways
ZFYVE26 plays roles in autophagy and endocytosis pathways. It associates with proteins such as spatacsin and atlastin-1 in these pathways which together modulate membrane dynamics. In autophagy ZFYVE26 ensures the maturation of autophagosomes while in endocytosis it facilitates the recycling of membrane constituents. These interactions ensure proper intracellular communication and material recycling important for cellular regular function.
Defects in ZFYVE26 cause hereditary spastic paraplegia (HSP) a disorder marked by spasticity and weakness of lower limbs. Mutations disrupt its function affecting endosomal pathway and axonal transport leading to neurodegeneration. It's closely associated with proteins like spatacsin in these pathological processes. Additionally ZFYVE26 has connections to amyotrophic lateral sclerosis (ALS) where defective endosomal systems and protein aggregation contribute to motor neuron degeneration and disease progression.