Abcam, ab31940, Anti-TBR1 antibody

Size: 100µg
Anti-TBR1 antibody (ab31940) is a rabbit polyclonal antibody detecting TBR1 in Western Blot, IHC-P . Suitable for Human, Mouse, Rat . - Over 470 publications - Trusted since 2006
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-TBR1 antibody (ab31940) is a rabbit polyclonal antibody and is validated for use in IHC-P, WB.
Anti-TBR1 antibody (ab31940) has been cited over 476 times in peer reviewed journals and is trusted by the scientific community.
Abcam's high quality validation processes ensure Anti-TBR1 antibody (ab31940) has high sensitivity and specificity.
Anti-TBR1 antibody (ab31940) has 31 independent reviews from customers.
Anti-TBR1 antibody (anti-HPRT antibody) (ab31940) specifically detects TBR1 (UniProt ID: Q64336; Molecular weight: 74kDa) and is sold in 100 µg selling sizes.
TBR1 (T-Box Brain Transcription Factor 1) is a transcription factor that is crucial for brain development, particularly in the formation of the cerebral cortex. It regulates the expression of genes involved in neuronal differentiation and migration. Mutations in the TBR1 gene are associated with neurodevelopmental disorders, including autism spectrum disorder and intellectual disability, where they disrupt normal brain development and function.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBR1 also known as T-Box Brain 1 is a transcription factor important for neuronal development. It weighs about 74 kDa. This protein is strongly expressed in the cerebral cortex during prenatal stages where it plays a role in regulating gene expression. TBR1 influences the differentiation and migration of cortical neurons which is critical for proper brain development.
Biological function summary
TBR1 influences neuronal differentiation through its function as a transcription factor. It binds to specific DNA sequences to regulate gene expression required for neuronal identity and function. TBR1 is part of a larger transcriptional complex that includes other proteins like CASK and TBR2 contributing to the maturation of cortical neurons. TBR1's role in these processes highlights its significance in neuronal circuit formation in the cerebral cortex.
Pathways
TBR1 is involved in the Wnt signaling and the reelin pathway which are both essential for normal brain development. In the Wnt signaling pathway TBR1 interacts with proteins such as LEF1 to influence cell fate decision and pattern formation. In the reelin pathway TBR1 work along with proteins like Reelin itself to regulate neuronal positioning promoting the correct layering of the cortex.
TBR1 has strong associations with autism spectrum disorders and intellectual disabilities. Mutations in TBR1 disrupt its role in gene regulation during brain development leading to the aforementioned neurological conditions. TBR1 also interacts with FOXP2 a protein involved in language and speech linking it further to communication-related aspects of these disorders.