Abcam, ab31951, Anti-SARS E2 antibody [4A6C9] - Coronavirus

Size: 100µL
Mouse Monoclonal SARS E2 antibody. Suitable for ELISA, WB and reacts with SARS-CoV samples. Cited in 1 publication.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4A6C9,
Isotype:IgG1,
Carrier free:No,
Reacts with:SARS-CoV,
Applications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
Applications overview
Tick: Tested and Guaranteed to work X: Will not work —: No data

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SARS E2 protein also known as the envelope or E protein is a structural component of the SARS coronavirus. It has a molecular mass of about 8.4 kDa. The E2 protein is expressed on the envelope of the SARS coronavirus where it plays an important role in virus assembly budding and pathogenesis. This protein assists in the formation of the viral envelope by interacting with other viral components and host cell membranes facilitating the release of new virions from the host cell.
Biological function summary
The SARS E2 protein functions in the assembly of virions and is part of a larger viral protein complex. This protein is involved in the regulation of the host's intracellular membrane trafficking which impacts viral replication and release. The E2 protein exhibits ion channel activity known as a viroporin influencing various host cellular processes including stress response and apoptosis.
Pathways
The SARS E2 protein interacts with early endosomal and Golgi pathways which are critical for viral trafficking within the host cell. It shares functional relations with other SARS coronavirus proteins such as the M (membrane) and S (spike) proteins. These interactions allow the virus to efficiently package and release infectious particles. The E2 protein also influences pathways associated with inflammation and immune evasion contributing to the virus's ability to persist and cause disease.
The SARS E2 protein is directly associated with severe acute respiratory syndrome (SARS) and coronavirus disease (COVID-19). Its interaction with the host cell's pathways can exacerbate inflammation and immune dysfunction leading to severe respiratory symptoms. Connections exist between the E2 protein and proteins involved in the host's inflammatory response such as cytokines which can result in a cytokine storm a critical factor in disease progression and severity in SARS and COVID-19 patients.