Abcam, ab320001, Anti-Norovirus Capsid protein VP1 antibody [SM59] - BSA and Azide free

Size: 100µg / 1mg
Mouse Recombinant Monoclonal CAPSD antibody. Carrier free. Suitable for WB, I-ELISA and reacts with Recombinant fragment - Norovirus samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SM59,
Isotype:IgG1,
Carrier free:Yes,
Reacts with:Norovirus,
Applications:I-ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody has been tested with recombinant Norovirus Capsid protein VP1 protein only.

Product details:
ab320001 is the carrier-free version of
ab256369
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Norovirus Capsid protein VP1 also known as the Norwalk Capsid protein is a major structural component of noroviruses. The mass of this protein is approximately 58 kilodaltons. It is expressed within the viral particles forming the outer shell or capsid which plays an important role in protection and infectivity of the virus. VP1 is also the main target for capsid ELISA tests which are employed for virus detection.
Biological function summary
Norovirus Capsid protein VP1 assembles into icosahedral particles forming the structure that encases the viral RNA. It works as part of a complex with other molecular groups to facilitate the virus’s entry into host cells by binding to histo-blood group antigens found on epithelial cells of the digestive tract. This protein’s structure allows it to adapt and evade the host immune response which plays role in the virus's infectivity.
Pathways
Norovirus Capsid protein VP1 involves in pathways related to viral replication and immune evasion. Inside the host it participates in interactions that inhibit immune signaling pathways. These interactions often involve proteins like the Golgi-associated mechanics to promote efficient assembly and release of viral particles. VP1's interaction with cellular machinery ensures ongoing propagation of the virus.
The Norovirus Capsid protein VP1 directly connects to gastroenteritis a leading cause of acute viral gastroenteritis. It links to disease progression by aiding viral invasion and persistence in the gastrointestinal tract. The VP1's interactions with the immune system and histo-blood group antigens contribute to high transmissibility and variability of infection severity among different individuals.