Abcam, ab320092, Anti-SARS-CoV2 nsp7 antibody [EPR24846-6]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal R1AB antibody. Suitable for WB, I-ELISA and reacts with Transfected cell lysate - SARS-CoV-2, Recombinant full length protein - SARS-CoV-2 samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24846-6,
Isotype:IgG,
Carrier free:No,
Reacts with:SARS-CoV-2,
Applications:I-ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SARS-CoV2 non-structural protein 7 (nsp7) also known simply as nsp7 plays a critical role in the replication machinery of the virus. It is part of the coronavirus replication and transcription complex and associates with other non-structural proteins to aid in RNA synthesis. Nsp7 has a molecular mass of approximately 8.4 kDa. It is predominantly expressed in host cells infected with the SARS-CoV2 virus especially in the lung tissue where the virus primarily resides and replicates.
Biological function summary
Nsp7 serves as a scaffold that binds to other proteins to form a stable complex essential for viral replication. It is part of the polymerase complex with other non-structural proteins such as nsp8 and nsp12. This complex is responsible for the accurate synthesis of RNA thereby ensuring the propagation of the viral genome. The interaction between nsp7 and its partner proteins is fundamental for boosting the efficiency and fidelity of the replication process.
Pathways
Nsp7 participates directly in the viral RNA synthesis and replication pathways required for SARS-CoV2 replication. The complex which includes nsp12 as the RNA-dependent RNA polymerase and nsp8 working alongside nsp7 facilitates the elongation of the viral RNA chains. These interactions are a critical part of the RNA synthesis pathway which directly connects to the larger context of viral proliferation within the host organism.
SARS-CoV2 nsp7 is directly linked to COVID-19. This virus causes respiratory illnesses ranging from mild symptoms to severe acute respiratory syndrome. The replication and transcription complex which nsp7 is a part of plays a significant role in the progression of the disease. As the virus replicates it causes widespread infection in the respiratory tract leading to the symptoms associated with COVID-19. Therefore nsp7 through its interactions with proteins like nsp12 becomes an interesting target for drug development aiming to thwart virus replication and more effectively treat COVID-19.