Abcam, ab320743, Anti-GIRK1 antibody [EPR29281-68]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal GIRK1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR29281-68,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Unsuitable for human IHC.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GIRK1 also known as Kir3.1 or KCNJ3 is a potassium channel protein that contributes to the regulation of potassium ion flow across cell membranes. It has a molecular mass of approximately 56 kDa. GIRK1 forms an important part of the inwardly rectifying potassium channels (Kir) and is expressed in various tissues most notably in the brain and heart. These channels allow the inward flow of K+ ions which are essential for many cellular processes.
Biological function summary
GIRK1 plays an important role in maintaining the resting membrane potential and neuronal excitability. It often forms a functional complex with other GIRK subunits such as GIRK2 and GIRK4 to mediate its effects. By responding to different neurotransmitters and coupling with G-protein-coupled receptors GIRK1 helps in neurotransmission regulation and contributes to the heart rate control.
Pathways
GIRK1 is involved in the G-protein coupled receptor (GPCR) signaling pathway and the atrial muscarinic acetylcholine receptor signaling pathway. This protein works closely with G-protein beta-gamma subunits which activate these pathways leading to increased potassium permeability. This regulation influences vital physiological processes like slowing the heart rate and modulating neural signals.
GIRK1 has connections to cardiac arrhythmias and epilepsy. Dysfunction in GIRK1-mediated channels can result in abnormal heart rhythms often linked with other proteins like GIRK4. In the nervous system aberrant GIRK1 function contributes to epilepsy by disrupting proper neuronal firing sometimes in association with altered G-protein signaling components. These associations highlight GIRK1 as a valuable target for therapeutic interventions in related disorders.