Abcam, ab321791, Anti-TGN38 antibody [EPR28143-541]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TGON3 antibody. Suitable for ICC/IF, WB, IHC-P and reacts with Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28143-541,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TGN38 also known as trans-Golgi network integral membrane protein 2 is a protein with a mass of approximately 38 kDa. It plays a role in the sorting and trafficking of proteins within the trans-Golgi network which acts as a hub for protein sorting and distribution in cells. It gets expressed mostly in the trans-Golgi network of various mammalian cells. TGN38 serves as a receptor that helps in the selection and distribution of proteins to their respective destinations maintaining intracellular protein transport efficiency.
Biological function summary
TGN38 contributes to the transport and stability of proteins within the Golgi apparatus though it does not form any known complex. The protein is involved in the retention and recycling of resident Golgi proteins helping maintain the functionality of the Golgi network. TGN38 coordinates with other cellular components to regulate the movement of proteins through secretory pathways which is essential for proper cellular function and protein distribution processes.
Pathways
TGN38 participates in the vesicular transport pathway and cisternal maturation models. It links to proteins like coated vesicle proteins and SNAREs that assist in the formation and movement of vesicles carrying proteins through cellular compartments. TGN38 helps ensure that proteins reach their correct destination interacting with these pathways to maintain efficient transport and secretion within the cell.
TGN38 shows connections with conditions related to protein trafficking and secretion defects such as hereditary spastic paraplegia. Aberrant function or expression of TGN38 can disrupt normal protein sorting contributing to these disorders. In particular it interacts with proteins like atlastin-1 which are also involved in maintaining the integrity of intracellular trafficking and are implicated in the pathogenesis of some neurological disorders.