Abcam, ab322039, Anti-TAP1 antibody [EPR26236-92]

Size: 100µL / 1mL
Anti-TAP1 antibody [EPR26236-92] is a Rabbit Monoclonal antibody that is used in TAP1 Dot Blot, IHC-P, Western Blot. Suitable for Human samples. Transporter associated with antigen processing 1 (TAP1) is a molecule involved in processing and presentation of major histocompatibility complex class I restricted antigens, including tumor-associated antigens. TAP1 participates in tumor immunity, and is aberrantly expressed in multiple cancer types, including in bladder cancer, small cell lung cancer, glioma, prostatic cancer, head and neck squamous cell carcinoma (HNSC), breast cancer, and colorectal cancer (CRC). Recently, TAP1 has been found to be a robust tumor prognostic biomarker and a novel predictor of clinical prognosis and immunotherapeutic responses in various cancer types
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26236-92,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The transporter associated with antigen processing 1 (TAP1) also known as ABCB2 is an ATP-binding cassette transporter with an important role in cellular immunity. TAP1 functions mechanically by transporting peptides from the cytosol into the endoplasmic reticulum. These peptides are typically 8-16 amino acids long and are processed for MHC class I molecules presentation. TAP1 has a molecular mass of approximately 75 kDa. Expression of TAP1 occurs primarily in cells of the immune system including lymphocytes and dendritic cells.
Biological function summary
TAP1 participates in the immune system by facilitating the presentation of peptide antigens to T cells. It forms a complex with TAP2 to transport antigenic peptides necessary for the proper functioning of the MHC class I pathway. This complex is essential for the immune system's ability to detect and respond to pathogens. Proper functioning of TAP1 ensures that peptides presented on MHC class I molecules are of endogenous origin allowing T cells to monitor cellular health and detect infected or transformed cells.
Pathways
TAP1 plays a role in the antigen processing and presentation pathway which is critical for adaptive immunity. This pathway involves specific steps in peptide processing where TAP1 along with TAP2 is essential for translocating peptides for binding to MHC class I complexes. Other related proteins in this pathway include calreticulin and tapasin which assist in peptide loading onto MHC class I molecules. Additionally TAP1 is involved in regulating cytosolic proteins' turnover through its role in transporting peptides that result from degraded proteins.
TAP1 dysfunction or variants can lead to immune system-related diseases such as Bare Lymphocyte Syndrome (BLS) a condition characterized by the lack of MHC class I molecule expression. This results in compromised immune surveillance and increased susceptibility to infections. TAP1 is also linked to autoimmune diseases where abnormal peptide presentation may occur. It is associated with proteins like HLA molecules which are often implicated in autoimmune pathogenesis. Analyzing TAP1 expression and function provides insight into these disorders' underlying mechanisms.