Abcam, ab32570, Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal

Size: 100µL / 1mL
Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) is a rabbit monoclonal antibody detecting PDGFR alpha in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC/IF, ELISA . Suitable for Human, Mouse, Rat . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 330 publications - Trusted since 2006
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:Y92,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:ELISA, WB, Flow Cyt (Intra), ICC/IF, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Expression levels of the target protein vary with sample type and some optimisation may be required.

Product details:
Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ELISA, Flow Cyt (Intra), ICC/IF, IHC-P, IP and WB.
Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) was first used in a scientific publication in 1984 and has been cited over 332 times in peer reviewed journals. It's performance in Western blot and IHC in human and mouse samples is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
The specificity of Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) has been confirmed by Western Blot testing in PDGFRB knockout SH-SY5Y cells (
ab273749
Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) has 31 independent reviews from customers.
Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal (ab32570) specifically detects PDGFR alpha (UniProt ID: P09619; Molecular weight: 121kDa) and is sold in 100 µL and 1 mL selling sizes.
Conjugation-ready, carrier free format available for antibody clone Y92 -
ab215978
Antibody clone Y92 is also available pre-conjugated to a variety of labels for your convenience - HRP, Alexa Fluor
488, Alexa Fluor
594, Alexa Fluor
405, PE, APC (
ab195515
ab196376
ab206872
ab206873
ab307638
ab314942
Top cited recombinant antibody to PDGRalpha and PDGRbeta on the market with >423 citations. PDGFR alpha and PDGFR beta are key markers in studying cell proliferation, differentiation and angiogenesis, making them invaluable biomarkers for cancer and vascular research
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Shipping conditions update: ambient shipping
This product will be delivered at ambient temperature instead of chilled – this is by design. Extensive stability testing confirmed that our products are suitable for shipment under ambient conditions and maintain expected quality.
Why the change?
It’s part of our commitment to more sustainable packaging solutions, with ambient deliveries using eco-friendly materials such as recyclable cardboard instead of polystyrene.
What you need to know
Ambient shipments come clearly marked on the delivery note.
No ice will be included in ambient shipments, but mixed orders (ambient and cold-chain items) will still arrive with ice packs to protect temperature-sensitive products.
Warranty coverage remains fully valid, aligned with our validated shipping method.
Please store the product as per the datasheet instructions upon receipt.
Find out more -
https://www.abcam.com/en-us/support/shipping-storage-support/ambient-shipping

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Conditional Ambient, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDGFR alpha and PDGFR beta are receptor tyrosine kinases also known as CD140a and CD140b. Both receptors have a molecular mass of about 180 kDa. PDGFR alpha is expressed in a variety of tissues including placenta astrocytes and vascular smooth muscle cells. PDGFR beta is more specific to fibroblasts smooth muscle cells and in the vascular system. These receptors bind platelet-derived growth factors (PDGFs) and become activated through dimerization and autophosphorylation.
Biological function summary
These receptors drive cellular processes like proliferation differentiation and migration. PDGFR alpha and beta operate as a significant part of a receptor complex. They modulate responses in mesenchymal cells and influence developmental pathways. In the vasculature system these receptors play roles in maintaining structure and function of blood vessels. Alterations in receptor activities can affect development of tissues and organs.
Pathways
PDGFR alpha and beta are key players in the PI3K-Akt signaling pathway and MAPK pathway. The activation of these pathways leads to cellular processes like survival and growth. PDGFR activity often interacts with other proteins such as SHP-2 RAS and Akt. These interactions contribute to the regulation of cellular responses to external growth signals embedding PDGFR in a web of intracellular cascade systems.
PDGFRs have linkage to conditions like cancer and fibrotic diseases. Aberrant PDGFR alpha activity has connections to glioblastoma while PDGFR beta alterations often relate to systemic sclerosis. These receptors can work alongside proteins like VEGF and TGF-beta within these diseases. Their dysregulation leads to pathological angiogenesis and abnormal cell proliferation making them targets for therapeutic intervention.