Abcam, ab32642, Anti-CACNA1A antibody

Size: 100µg
Rabbit Polyclonal CACNA1A antibody. Suitable for WB, IHC-FoFr and reacts with Mouse, Rat, Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-FoFr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CACNA1A also known as Cav2.1 is a voltage-gated calcium channel subunit with an important role in calcium ion transport across cell membranes. It belongs to the P/Q-type calcium channels and weighs approximately 250 kDa. This protein is widely expressed in the central nervous system particularly in the cerebellum and cerebral cortex where it has an important function in neurotransmission and synaptic activity.
Biological function summary
CACNA1A influences synaptic transmission by modulating calcium ion entry into neurons which triggers neurotransmitter release. It forms a component of a larger heteromeric complex that involves other subunits which help regulate channel activity and stabilization. By facilitating calcium influx it supports activities such as muscle contraction and signal transduction in neuronal circuits.
Pathways
This calcium channel subunit participates in the calcium signaling pathway and synaptic vesicle cycle. Through these pathways CACNA1A interacts with proteins like CACNB and CACNA2D which modulate its channel functions. These interactions help in the rapid signal transmission required for effective synaptic communication and overall cellular homeostasis.
Mutations or dysregulation of CACNA1A can lead to conditions like familial hemiplegic migraine and episodic ataxia type 2. It has associations with proteins such as IRS4 which may influence the onset or progression of these neurological disorders. Understanding these interactions aids in elucidating the molecular basis of such conditions and potentially guiding therapeutic strategies.