Abcam, ab33330, FITC Anti-HLA B7 antibody [BB7.1]

Size: 50µg
Mouse Monoclonal HLA B antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human, Cynomolgus monkey samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human HLA-B.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BB7.1,
Isotype:IgG1,
Conjugation:FITC,
Excitation/Emission:Ex: 495nm, Em: 519nm,
Carrier free:No,
Reacts with:Human, Cynomolgus monkey,
Applications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Full Length Protein corresponding to Human HLA-B. The exact immunogen used to generate this antibody is proprietary information.P01889,
Specificity:This antibody recognizes the HLA B7 antigen and does not cross react with HLA B27 or other related antigens.

Product details:
This antibody can be used to distinguish true HLA B27 positives from false HLA B27 positives (i.e. HLA B7 positive) in the investigation of diseases such as ankylosing spondylitis and anterior uveitis.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-This antibody was purified from tissue culture supernatant., Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HLA-B7 also known as HL-A B7 is a part of the human leukocyte antigen (HLA) system and belongs to the HLA class I heavy chain paralogs. This protein has a molecular mass of approximately 45 kDa. HLA-B7 is expressed on the surface of nearly all nucleated cells in the body. Its main role is to present peptide antigens to the immune system specifically to cytotoxic T cells which play an important part in immune response.
Biological function summary
HLA-B7 is involved in antigen presentation as a part of the major histocompatibility complex (MHC) class I molecule. HLA-B7 like other HLA class I molecules presents endogenous peptides to CD8+ T cells. The HLA B27 pair although different from HLA-B7 shares functional similarities that influence immune surveillance and activation processes.
Pathways
HLA-B7 participates in the antigen processing and presentation pathway. This pathway allows the presentation of intracellularly derived peptides at the cell surface which are recognized by T cell receptors (TCR) on CD8+ T lymphocytes. HLA-B7 works in concert with proteasomes for peptide generation and with transporter associated with antigen processing (TAP) for delivering peptides to the endoplasmic reticulum.
HLA-B7 is linked with certain autoimmune diseases and viral infections. Some studies suggest an association with increased susceptibility to diseases such as sarcoidosis. Moreover individuals who are HLA-B7 positive may differ in their immune response to viral infections like HIV. The interaction between HLA-B7 and proteins like beta-2 microglobulin further affects its role in disease mechanisms and immune function.