Abcam, ab33520, Anti-ATIC antibody [F38 P7 H9]

Size: 50µg
Mouse Monoclonal ATIC antibody. Suitable for Flow Cyt, WB, IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human ATIC aa 550 to C-terminus conjugated to Ovalbumin.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:F38 P7 H9,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ATIC aa 550 to C-terminus conjugated to Ovalbumin. The exact immunogen used to generate this antibody is proprietary information.P31939

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATIC also known as AICAR transformylase/IMP cyclohydrolase is a bifunctional enzyme involved in purine biosynthesis within cells. It has a molecular mass of approximately 64 kDa. This enzyme is found in various tissues including liver kidney and brain. It catalyzes the last two steps in the de novo purine biosynthesis pathway playing an important role in cellular proliferation and energy homeostasis.
Biological function summary
ATIC participates importantly in purine metabolism by facilitating the conversion of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) into inosine monophosphate (IMP). It acts both as a transformylase and cyclohydrolase forming part of the multi-enzyme purinosome complex. This involvement ensures efficient synthesis of IMP which is a precursor for adenosine and guanosine nucleotide production essential for DNA and RNA synthesis.
Pathways
ATIC is integral to the de novo purine biosynthesis pathway a critical cellular process for generating nucleotides. It interacts with other enzymes in this pathway such as phosphoribosylaminoimidazole carboxamide formyltransferase (PAIC) and adenylosuccinate lyase (ADSL) ensuring a steady supply of nucleotides. This pathway is also linked to the folate cycle highlighting the importance of ATIC in broader metabolic contexts.
ATIC has associations with several conditions notably cancer and autoimmune diseases. Its role in purine and folate metabolism makes it a target in cancer therapies where fast-dividing cells depend on nucleotide synthesis. ATIC also connects to dihydrofolate reductase (DHFR) due to the shared pathway implicating both in therapies aimed at autoimmune conditions like rheumatoid arthritis. Understanding ATIC's function and interaction plays a part in advancing disease treatment strategies.