Abcam, ab33636, Anti-Paramyxovirus Type 2 antibody

Size: 500µL
Chicken Polyclonal Paramyxovirus Type 2 antibody. Suitable for ELISA and reacts with Paramyxovirus sp. samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Paramyxovirus Type 2 protein.
Key facts
Host species:Chicken,
Clonality:Polyclonal,
Isotype:IgY,
Carrier free:No,
Reacts with:Paramyxovirus sp.,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody is monospecific.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Purification notes-This antibody is a sterile filtered serum produced in SPF (Specific Pathogen Free) chicken embryos., Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Add glycerol to a final volume of 50% for extra stability and aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Paramyxovirus Type 2 also known as Human parainfluenza virus type 2 (HPIV-2) is a virus that belongs to the Paramyxoviridae family. It is an enveloped virus with a negative-sense single-stranded RNA genome. The nucleocapsid proteins (N proteins) of HPIV-2 are key in its replication and assembly as they encapsidate the viral RNA into a helical structure. The Viral RNA polymerase complex which includes L and P proteins transcribes and replicates the genome within the infected cells predominantly in the epithelial cells of the respiratory tract.
Biological function summary
The infection caused by HPIV-2 induces inflammatory responses and can lead to illnesses such as croup bronchiolitis and pneumonia particularly in young children. HPIV-2 is not part of a larger complex but interacts with host cell receptors during entry. The virus uses its fusion (F) protein to merge viral and cellular membranes enabling its RNA to enter host cells and begin the replication cycle. This interaction is important for the spread of the virus within the host and between individuals.
Pathways
Scientists have shown that the HPIV-2 infection impacts the host's immune signaling pathways specifically interferon response pathways. The virus can modulate the Jak-STAT signaling pathway to evade the host's antiviral responses. It achieves this by using its accessory V protein which binds to and inhibits STAT proteins disrupting the normal signaling cascade and leading to reduced type I interferon production.
HPIV-2 is known to cause significant respiratory illnesses namely croup and pneumonia particularly in infants and immunocompromised individuals. The F protein of HPIV-2 is considered an important factor in the disease's pathogenesis as it facilitates the virus's entry and spread within the host. The N protein's role in stabilizing the viral RNA impedes immune detection contributing to the severity of these diseases.