Abcam, ab33637, Anti-Paramyxovirus Type 3 antibody

Size: 500µL
Chicken Polyclonal Paramyxovirus Type 3 antibody. Suitable for ELISA and reacts with Paramyxovirus sp. samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Paramyxovirus Type 3 protein.
Key facts
Host species:Chicken,
Clonality:Polyclonal,
Isotype:IgY,
Carrier free:No,
Reacts with:Paramyxovirus sp.,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody is monospecific.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Purification notes-This antibody is a sterile filtered serum produced in SPF (Specific Pathogen Free) chicken embryos., Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Add glycerol to a final volume of 50% for extra stability and aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Paramyxovirus Type 3 also known as human parainfluenza virus type 3 (HPIV3) is a member of the Paramyxoviridae family. This virus exhibits a genome composed of negative-sense single-stranded RNA and encodes six structural proteins. The virus particle measures approximately 150-250 nm in diameter and possesses a lipid envelope. HPIV3 is expressed in respiratory epithelial cells and is responsible for significant respiratory tract infections.
Biological function summary
The virus targets epithelial cells in the human respiratory tract causing cellular damage and inflammation. HPIV3 uses surface glycoproteins hemagglutinin-neuraminidase (HN) and fusion (F) protein to facilitate the attachment and fusion with host cells. These proteins form part of a complex responsible for host cell entry and viral replication. The fusion protein with a molecular weight of approximately 60 kDa is instrumental in the fusion process.
Pathways
Several other molecules play an important role in HPIV3's replication cycle. HPIV3 initiates the host cell entry pathway using attachment to the sialic acid receptors on the host cell surface via its HN protein. Its interaction in the fusion pathway is essential for virus entry and replicative cycle continuation. The fusion pathway resembles that of other paramyxoviruses like the respiratory syncytial virus (RSV) which also relies on surface glycoproteins for cell entry.
HPIV3 is linked to respiratory illnesses such as bronchiolitis and pneumonia especially in young children and immunocompromised individuals. The viral infection increases pro-inflammatory cytokines in the host exacerbating respiratory conditions. HPIV3-related pathologies are often related to the overactive immune response of the host and it shares pathogenic pathways with RSV often compounding the severity of respiratory illnesses.