Abcam, ab33718, Anti-Marek’s Disease antibody

Size: 500µL
Chicken Polyclonal Marek’s Disease antibody. Suitable for ELISA and reacts with Gallid alphaherpesvirus 2 samples. Cited in 1 publication.
Key facts
Host species:Chicken,
Clonality:Polyclonal,
Isotype:IgY,
Carrier free:No,
Reacts with:Gallid alphaherpesvirus 2,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody is monospecific for Marek s Disease.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Purification notes-Sterile filtered serum produced in SPF (Specific Pathogen Free) chicken embryos., Storage buffer-Constituents: Whole serum, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Marek's Disease is caused by the Marek's Disease Virus (MDV) which is a highly contagious herpesvirus affecting poultry. Mechanically the virus targets lymphocytes leading to the transformation and proliferation of these immune cells. The outer structure of MDV contains a capsid that aids in the protection and delivery of viral genetic material with virus particles having a molecular mass of large and complex structures. The virus is predominantly expressed in feather follicle epithelium cells facilitating transmission among birds during close contact.
Biological function summary
The transformation of lymphocytes results in lymphoid neoplasms that disrupt normal immune function in birds. The Marek's Disease virus integrates into the host genome which plays a major role in its ability to induce tumorigenesis. The virus forms a latency-associated complex that allows it to evade host immune surveillance. This complex allows MDV to persist lifelong in the infected host which may cause health complications over time for the affected poultry.
Pathways
The Marek's Disease virus is deeply involved in oncogenic pathways. It engages the Jak-STAT signaling pathway which contributes to cell growth and proliferation facilitating tumor formation. The virus interacts with viral proteins like Meq which is homologous to the Jun/Fos proto-oncogenes influencing cell cycle regulation and apoptosis inhibition. These interactions reinforce the virus's ability to induce neoplastic disease in poultry.
Marek's Disease stands out as a significant concern in poultry farming leading to economic losses and trade restrictions due to the associated lymphoproliferative disorder. The disease also makes birds more susceptible to other infections by compromising immune defenses. Meq protein a critical player in the disease's pathology serves as an important biomarker for diagnosing the presence and progression of Marek's Disease which can be critical for managing and controlling outbreaks.