Abcam, ab34151, Anti-Caspr antibody

Size: 100µg
Anti-Caspr antibody (ab34151) is a rabbit polyclonal antibody detecting Caspr in Western Blot, IP, ICC/IF . Suitable for Human, Mouse, Rat . - KO validated for confirmed specificity - Over 80 publications - Trusted since 2007
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Product Specifications
Anti-Caspr antibody (ab34151) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IP, WB in human, mouse and rat samples.
Anti-Caspr antibody (ab34151) specifically detects Caspr (UniProt ID: P78357; Molecular weight: 154kDa) and is sold in 100µg selling sizes.
Quality and Validation
Abcam's high quality validation processes ensure Anti-Caspr antibody (ab34151) has high sensitivity and specificity.
The specificity of Anti-Caspr antibody (ab34151) has been confirmed by testing in knockout samples.
Anti-Caspr antibody (ab34151) has been cited over 81 times in peer reviewed journals and is trusted by the scientific community.
Anti-Caspr antibody (ab34151) has 8 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Caspr also known as contactin-associated protein 1 (CNTNAP1) is a transmembrane protein important for axonal function. It is approximately 190 kDa in size. Caspr is expressed mainly in neurons specifically at the paranodal regions of myelinated axons. This location is important for nerve impulse propagation demonstrating its structural and functional roles in the nervous system.
Biological function summary
Caspr interacts with other proteins at the paranodes forming a complex with contactin and Neurofascin 155. This complex contributes to the insulation and maintenance of the nerve's myelin sheath. By ensuring proper node of Ranvier organization Caspr supports efficient saltatory conduction. The protein's interaction within these complexes allows axons to transmit signals rapidly and accurately.
Pathways
Caspr plays an important role in the maintenance of nervous system architecture and function. It is integral to the axoglial junctions and participates in the clustering and distribution of ion channels which are essential components of the nervous system. Caspr regulates these processes by interacting with proteins such as contactin and Neurofascin facilitating the communication and signaling pathways necessary for nervous system homeostasis.
Caspr dysfunction is linked to conditions such as multiple sclerosis and hereditary neuropathies. Abnormalities in Caspr or its associated complexes can lead to myelination defects and impaired nerve transmission. The protein's involvement in these diseases often relates to its association with contactin and other neuronal proteins highlighting its significance not only in healthy nervous system function but also in pathologies that affect nerve conduction.